Multifunctional and Self‐Healing Oxidized Bacterial Nanocellulose‐Based Composite Hydrogels with pH‐Switchable Cascade Enzyme Catalytic Activity for Accelerating Diabetic Wound Healing

Key Points

• This research investigates the effectiveness of a hydrogel that promotes wound healing in diabetic individuals.
• GOD@H hydrogel was applied to wounds to assess healing efficacy and tissue toxicity.
• Complete re-epithelialization was evaluated within 14 days post-application.
• Integrative functions such as glucose regulation and antibacterial action were tested.
• Wound closure was significantly accelerated with complete re-epithelialization achieved in 14 days.
• Minimal tissue toxicity was observed during treatment, indicating safety.
• The hydrogel demonstrated effective glucose regulation and antibacterial properties.

Abstract