Cytocompatibility of Three Calcium Silicate-Based Biomaterials: A Systematic Review and Meta-Analysis.

Introduction: cytotoxic effects of three calcium silicate-based cements Mineral Trioxide Aggregate (MTA), Biodentine, and Calcium Enriched Mixture (CEM) Cement, focusing on their biocompatibility with human dental pulp cells in vital pulp therapy (VPT). Materials and Methods: ., MTT) were included. Results: <0.05). No other concentrations or exposure durations showed significant cytotoxic effects. CEM cement consistently demonstrated favorable biocompatibility across the included studies. Conclusion: biocompatibility for vital pulp therapy. Their biological responses may be influenced by material concentration and exposure duration, emphasizing the importance of careful and controlled clinical application.