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formation of copper nanoclusters (CuNCs), thus producing a label-free fluorescence signal within 2 h. In this design, magnetic beads not only facilitate efficient separation from serum matrices but also enhance reaction efficiency through surface-initiated enzymatic polymerization. As a result, the sensing platform exhibits excellent specificity, including reliable discrimination of single-base mismatches, and maintains robust performance in complex biological samples. This integrated platform, combining bioinformatic prescreening with a CuNCs-based sensing strategy, offers rapid, cost-effective, and label-free detection of miRNA, showing promise for early diagnosis and clinical monitoring of endometriosis.
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Y H Wu
Hsu-Ching Yen
Pao‐Ling Torng
Analytical Chemistry
National Taiwan University
National Taiwan University Hospital
Advanced Materials and Devices (United States)
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Wu et al. (Thu,) studied this question.
www.synapsesocial.com/papers/6a080acea487c87a6a40cc4a — DOI: https://doi.org/10.1021/acs.analchem.6c00532