Structure-Activity Relationships of ATCUN-Based Cu(II) Complexes with Large Chelate Rings: Interplay of ROS Generation, DNA Binding, and Nuclease Activity

Since the discovery of DNA cleavage and anticancer activity of the simplest Cu(II) ATCUN complex (peptide ligand: Gly-Gly-His, GGH) in 1983, systematic biological enhancements by derivatives have not been achieved....